Penetrating insights?

Penetrating insights?

In this special Frontiers in Microbiology issue focusing on “Global host proteomic responses to virus infection,” Coombs and colleagues (Jiang et al., 2012) make a valiant effort to look deeper into (changes in) the proteome of HeLa cells upon reovirus infection. Using some of the latest proteomic techniques, they present a high quality analysis of quantified alterations in the protein content ...

Structural analysis of ‘‘flexible’’ liposome formulations: new insights into the skin-penetrating ability of soft nanostructures

Self-assembled nanocontainers that can penetrate the protective barrier of skin could prove useful for the needle-free delivery of chemicals, drugs or vaccines into the skin. The main examples of these are the so-called ‘‘flexible liposomes’’, which are mixtures of lipids and detergents. In vitro experiments by numerous researchers have confirmed the skin-penetrating ability of these structures...

Frequency Dependence of Attenuation in Ground-Penetrating Radar: Insights from the Bishop Tuff

Total attenuation in ground-penetrating radar (GPR) was directly measured in radargrams of the Bishop Tuff, CA, from 12.5–200 MHz. The weak variation of attenuation with frequency reaffirms the "GPR Plateau" concept and argues against a constant-Q model. Electrolytic absorption —determined using collocated DC resistivity profiling/ sounding—accounts for about half of the attenuation and is by d...

A Penetrating Pellet Jeopardizing Internal Carotid Artery

Experimental orthotopic penetrating keratoplasty--a rat penetrating keratoplasty model.

An orthotopic penetrating keratoplasty model was developed in the rat. An oversized (0.5 mm) graft was used and 8 interrupted sutures were applied. These sutures were not removed. Eleven grafts out of 13 were rejected by the 3rd week in the disparate group (Brown Norway rat to Lewis rat transplantation group), which was characterized by edema, opacity, and neovascularization. All grafts remaine...